Cold Atmospheric Plasma (CAP) on interaction with water in hydrogel matrices creates Reactive Oxygen Species (ROS), primarily hydrogen peroxide. Hydrogen peroxide has disinfectant properties, but can also be used to trigger release of other antimicrobial moities.
We are binding antimicrobial molecules to the wound dressing hydrogel matrix and using the hydrogen peroxide generated by the CAP to initiate release of antimicrobials / antibiofilm agents into the wound. Synergy between hydrogen peroxide and the released antimicrobial will ensure enhanced wound disinfection, all achieved without the need to disrupt healing by removing the dressing
Diabetes is the most common cause of non‑traumatic limb amputation, with infected diabetic foot ulcers preceding more than 80% of amputations in people with diabetes. After a first amputation, people with diabetes are twice as likely to have a subsequent amputation as people without diabetes. Mortality rates after diabetic foot ulceration and amputation are high, with up to 70% of people dying within 5 years of having an amputation and around 50% dying within 5 years of developing a diabetic foot ulcer.